Anti-implantation and abortifacient effects have been demonstrated in female rodents and rabbits, whereas reduced sperm counts and motility, genetic damage in germ cells, and toxic effects on testicular tissue were seen in male animals. In vitro studies have indicated that this amino acid directly stimulates pancreatic beta-cells. Reductions of serum cholesterol (15% to 33%) from baseline were reported in all the trials identified.47 Results from further studies conducted among patients with diabetes found equivocal results, with most reporting decreases in total cholesterol, triglycerides, and low-density lipoprotein.8, 34, 89, Antifungal and antibacterial properties have been demonstrated.17 A French patent was granted to a product containing extracts of several herbal products, including fenugreek, purported to have activity against human and animal flagellate parasites.48, Oral administration of fenugreek seed fractions and fiber products resulted in dose-dependent gastric protection similar to that of nonprescription antacid medication.17, 49, 50, 77 Because of the association of Helicobacter pylori with gastritis, peptic ulcer, and gastric cancer, in vitro experimentation was conducted in H. pylori-infected gastric epithelial cells with 24 medicinal plants indigenous to Pakistan to evaluate their effect on secretion of IL-8 and generation of reactive oxygen species (ROS) in order to assess anti-inflammatory and cytoprotective effects. Every plant has different names in different languages. Bleeding may occur. Learn more about Fenugreek uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Fenugreek A Cochrane systematic review and meta-analysis of dietary supplements for dysmenorrhea identified only low or very low quality studies with very small sample sizes. You can also know the Fenugreek Scientific Classification which will help you gain the botanical information about the plant. As an herbal remedy, this is one of the most common uses and if true, it might be related to the seeds’ effect on estrogen and prolactin levels. Transient and mild GI effects were the most commonly reported side effects in fenugreek groups; however, comparisons could not be drawn with hypoglycemic agents due to a lack of data on the latter. In a screening study, fenugreek exhibited activity in a monoamine oxidase type A assay but did not demonstrate affinity for the serotonin transporter.30 In a model of sciatic nerve injury in rats, an extract of fenugreek restored motor nerve conduction but not nerve ligation.31 In a model of Parkinson disease in rats, fenugreek seed extract demonstrated neuroprotective effects and reversed motor-related symptoms.32, A small clinical study evaluated the effect of adjuvant standardized hydroalcoholic extract of fenugreek seeds in patients with Parkinson disease. Here are common names of Fenugreek: There are currently no items in this table. Another hypothesis attributes the cholesterol-lowering activities to the fiber-rich gum portion of the seed, which reduces the rate of hepatic synthesis of cholesterol. it made sourcing for it more easy for me. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. There are many testimonials and positive reviews by women who claim it makes their breast larger, but there’s no scientific validation of these claims. Fenugreek may lower blood glucose and cholesterol levels in people with diabetes. Select one or more newsletters to continue. Neither dose produced a significant reduction in postprandial blood glucose.76, A systematic review and meta-analysis identified 10 clinical trials that evaluated the effect of fenugreek intake on glucose homeostasis markers including fasting blood glucose, 2-hour postload glucose, HbA1c, and fasting serum insulin levels. The plant bears grey-green, tripartite, toothed leaves, and white or pale yellow flowers appear in summer and develop into long, slender, sword-shaped seed pods with a curved, beaklike tip. Last updated on Dec 20, 2018. When ingested in culinary quantities, fenugreek is usually devoid of adverse reactions.64 Mild transient GI effects (ie, dyspepsia, abdominal distention, diarrhea, flatulence, nausea) have been reported with chronic administration in diabetic patients as well as healthy adults in clinical studies and case reports with dosages ranging from 1 mg/day hydro-alcoholic seed extract for 2 months to 12.5 g fenugreek seed powder given twice daily for up to 24 weeks.2, 65, 90 Uncompensated coagulation failure in a patient with cirrhosis was believed to be attributed to coumarins from long-term, high doses of fenugreek-based porridge.91, Hypoglycemia has been reported in diabetic and healthy adults given 100 g of defatted fenugreek seed powder for as little as 10 days. Monitor therapy.61, 62, 63, 78, Fenugreek is generally recognized as safe for use both as a spice and as a fiber. Common Problems. Fenugreek extracts are also used in soaps and cosmetics. Fenugreek is a plant also known as Alholva, Bird's Foot, Bockshornklee, Bockshornsame, Chandrika, Fenogreco, Foenugraeci Semen, Greek Clover, Greek Hay, Greek Hay Seed, Hu Lu Ba, Medhika, Methi, Sénégrain, Trigonella, Woo Lu Bar, and other names. Three minor steroidal sapogenins, smilagenin, sarsasapogenin, and yuccagenin, also have been found in the seeds.9, 10 The lactone sotolone is responsible for the plant's characteristic smell. In all 10 studies, significant effects were observed on fasting blood glucose (FBG) compared with controls (P < 0.001) in patients with diabetes (types 1 and 2) but not in participants without diabetes; doses less than 5 g/day were unlikely to produce effects. It is not only used in cooking, but also used for medicinal purposes. When ingested in culinary quantities, fenugreek is usually devoid of adverse reactions. Fenugreek is a widely used herbal agent, but data are insufficient to determine its efficacy and safety. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. No, fenugreek does not boost either free or total testosterone levels according to the scientific evidence at hand. Fenugreek is a plant that belongs to Fabaceae family, is also called methi in India. The plant thrives in full sun and in rich, well-drained soils, and has a spicy odor that remains on the hands after contact.1, 2, Fenugreek herb has been used for centuries as a cooking spice in Europe and remains a popular ingredient in pickles, curry powders, and spice mixtures in India and other parts of Asia. It develops over time, according to use, look, and lore. Only 1 study out of 7 showed an effect on insulin.44 Study methodology limitations exist. Limited clinical trial data suggest fenugreek extracts may have a role in the therapy of dyslipidemia, diabetes, and Parkinson disease; however, studies were limited and provided inconsistent dosing information, making it difficult to provide recommendations. One small clinical study was conducted among patients with type 1 diabetes, and the balance was conducted among healthy participants or those with type 2 diabetes.8, 36 Most studies found a reduction of fasting blood glucose of 30 to 45 mg/dL,8, 43 and some showed a decrease in glycosylated hemoglobin. It is … Fenugreek can be used as a vegetable, as seeds, or as dried herbs. Perennial Flowers + Moneyplant. The C-glycoside flavones vitexin, vitexin glycoside, and the arabinoside isoorientin have been isolated from the plant. Common Name: Fenugreek Scientific Name: Trigonella foenum-graecum Other Names: Bird’s Foot, Bockshornklee, Greek Hay Seed Description Fenugreek is an annual plant belonging to the Fabaceae family. The use of fenugreek dates back to around 4000 BC. It is cultivated and used all around the world, but mainly in India. Studies in pregnant mice and rats have shown intrauterine growth retardation, fetal malformations, and increased fetal mortality related to fenugreek seed consumption and various other preparations (ie, crude non-polar steroidal fraction of fenugreek seed, fenugreek alcohol extract, fenugreek seed powder, saponin extract, decoction from fenugreek leaves). Can fenugreek increase breast size? Consider therapy modification.56, 57, 58, 59, 78, Herbs (anticoagulant/antiplatelet properties): May enhance the adverse/toxic effect of other herbs (anticoagulant/antiplatelet properties). Phytother Res 2011;25:88-91) ~ Fenugreek has been shown to increase the production of milk in nursing mothers (Forinash, A. It is used both as an herb, from the leaves of the plant, and as spice, from the seeds. Fenugreek oilextracted from the fenugreek seeds is also used for diabetes control, muscle spasm, enh… The availability of only 1 study for pre-diabetes limited the usefulness of disease subgroup analysis. For centuries, fenugreek has been taken to promote health and well-being. Fecal bile acid and cholesterol excretion are increased by fenugreek administration.3 This may be secondary to a reaction between the bile acids and fenugreek-derived saponins causing the formation of micelles too large for the digestive tract to absorb. Common effective dosages are around 1000mg. Fenugreek Herb Notes / Side Effects Latin Name. Although no significant direct cytotoxic effects on the gastric cells or bactericidal effects on H. pylori were found, fenugreek was observed to have mild and moderate inhibitory activity on IL-8 at 50 and 100 mcg/mL, respectively, in H. pylori-infected gastric cells.85, Reduction in cataract incidence was demonstrated in diabetic rats receiving an extract of fenugreek seeds and leaves. In folk medicine, fenugreek has been used to treat boils, cellulitis, and tuberculosis. Big leaf Maple. These galactomannans have a unique structure and may be responsible for some of the characteristic therapeutic properties attributed to fenugreek.3, The use of fenugreek has been limited by its bitter taste and pungent odor. This form of cancer, which is common anywhere in the world, can fortunately be prevented with the help of anti-cancer foods such as fenugreek. No adverse effects were reported or observed with fenugreek extract.87. This herb may have numerous health benefits. Each of the 8 individual climacteric subscale scores was also significantly improved with the fenugreek extract (P < 0.01). Very limited evidence of effectiveness was found for the treatment of primary dysmenorrhea with fenugreek compared to placebo or no treatment (1 randomized clinical trial, N = 101). Fenugreek seed powder dosage was 1.8 to 2.7 g taken 3 times daily for the first 3 days of menstruation (total daily dose, 5.4 to 8.1 g). Fenugreek is an herb long used in alternative medicine. Unfortunately, it seems that most supplement companies start their ingredient formulations in the marketing room instead of with scientific data. Crookneck Squash. From my experience, even bean beetles don’t seem to realize this plant is a legume. Fenugreek (Methi) seeds are most commonly used as medicine in Ayurveda as well folk medicine. A clinical trial evaluated the effects of fenugreek fiber 4 and 8 g at breakfast in adult non-diabetic patients with a body mass index of 30 or higher. A study conducted in 2011 evaluated the efficacy of fenugreek as a galactogogue; however, the extent of transmission of fenugreek-derived constituents into breast milk is unknown and efficacy has yet to be established.55 Compared to placebo and other galactogogues in a network meta-analysis (N=242; range, 22 to 122), fenugreek produced significantly more breast milk than placebo but not Coleus amboinicus or palm dates. Common English name: Fenugreek, bird ‘s foot, Fresh Menthi, Greek -clover, Greek Hay, Sicklefruit, Cooper’s Clover Etymology: Fenugreek is derived from foenum- graecum, which in turn gives the scientific name of this plant.Foenum – graecum means ” Greek hay “. No side effects were observed.84, High levels of polyphenolic flavonoids (more than 100 mg per 100 g) have been isolated from fenugreek seeds.17 These were associated with dose-dependent protection of erythrocytes from antioxidant damage in an in vitro study.18, Models of toxicity in laboratory studies (including cardio-, hepato-, nephro-, and neurotoxicity) have shown that fenugreek exerts antioxidant protective effects.19, 20, 21, 22, 23. Each pod contains about 10 to 20 small, yellowish-brown, angular seeds, which are dried to form the commercial spice. These effects were observed at a dose as low as 100 mg/kg/day, a human dose equivalent of 16.2 mg/kg (972 mg/60 kg).17, 52, 90 In humans, congenital malformations (ie, hydrocephalus, anencephaly, cleft palate, spina bifida) have been reported in offspring of women who consumed fenugreek seeds during pregnancy.90. Wide-ranging dosages and differing preparations have been used in clinical studies. The seeds also contain the saponin fenugrin B. Diosgenin, a precursor used in commercial steroid synthesis, is extracted from the seeds. Plant tissue cultures from seeds grown under optimal conditions have been found to produce as much as 2% diosgenin with smaller amounts of gitongenin and trigogenin. This in turn reduces the likelihood of these clots blocking tiny blood vessels, or even larger blood vessels which are important to the brain or heart itself. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Common Name of Fenugreek in other languages is an interesting information one should know. The mucilages of fenugreek's and several other plants' seeds have been determined and their hydrolysates analyzed.11 Fenugreek gel consists chiefly of galactomannans, characterized by their high water-holding capacity. Outcome measures included the Unified Parkinson's Disease Rating Scale (UPDRS), and Hoehm and Yahr (H & Y) staging measured at baseline and at 6 months. HbA1c was also significantly reduced compared with controls (P = 0.009); however, fasting serum insulin levels were not significantly different. Fenugreek has very few problems in an organic garden. Scientific Name(s): Trigonella foenum-graecum ï»¿L.Common Name(s): Faenum graecum, Fenugreek, Huluba, Methi, Semen Trigonellae. While the seeds and leaves are primarily used as a culinary spice, it is also used to treat a variety of health problems in Egypt, Greece, Italy, and South Asia. Common name of Fenugreek is the name which changes with change in the regions. Fenugreek has documented uterine stimulant effects and has been used in traditional medicine to induce childbirth and hasten delivery by promoting uterine contractions. Bleeding may occur. Fenugreek is a common ingredient in spice powders in Indian cuisine. We comply with the HONcode standard for trustworthy health information -, http://www.faqs.org/patents/app/20110123656, http://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm091048.htm. Available for Android and iOS devices. I appreciate your effort to give us local names of all these plants. Fruits + Chicago Hardy Fig. Bleeding may occur. Consider therapy modification.56, 57, 58, 59, Salicylates: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of salicylates. The main purpose of having a scientific name is to have a same name accepted and used worldwide. Overall, the number of severe liver injury cases was significantly higher from supplements than conventional medications (P=0.02). Studies in patients with type 2 diabetes and hypercholesterolemia have used 5 g/day of seeds or 1 g/day of a hydroalcoholic extract of fenugreek.34, A trial in patients with Parkinson disease evaluated the safety of a standardized hydroalcoholic extract of fenugreek seeds at a dosage of 300 mg twice daily over 6 months.33, Fenugreek seed powder 1.8 to 2.7 g taken 3 times daily for the first 3 days of menstruation was used in primary dysmenorrhea (total daily dose, 5.4 to 8.1 g).84, Avoid use in pregnancy. Fenugreek powder is the dust form of the spice and is easily available in the market. Consider therapy modification.56, 57, 58, 59, Anticoagulants: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of anticoagulants. Fenugreek seeds, also known as methi seeds, are a common ingredient in Indian curries, as well as Turkish, Persian, Eritrean, Ethiopian, and Egyptian cuisine. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. The seeds are rich in protein, and the plant is grown as animal forage. Cross-reactivity to chickpea, peanut, or coriander allergy is possible. What is Fenugreek? Fenugreek showed greater efficacy than placebo, but further, larger trials are required to determine if fenugreek has a place in the treatment of Parkinson disease.33 A double-blind, placebo-controlled trial found clinically significant beneficial changes in total and motor UPDRS scores as well as H & Y staging for 42 early Parkinson patients taking 300 mg twice daily of a standardized fenugreek extract for 6 months as a nutritional adjuvant to levodopa/carbidopa therapy.82, The galactomannan-rich soluble fiber fraction of fenugreek may be responsible for the antidiabetic activity of the seeds.3 Insulinotropic and antidiabetic properties also have been associated with the amino acid 4-hydroxyisoleucine, which occurs in fenugreek at a concentration of about 0.55%. The primary inclusion criterion was last menses between 12 months and 3 years; although, the authors noted ambiguously that the last menstrual period in participants of both groups was noted to have occurred before 12 months. Limited clinical trial data suggest fenugreek extracts may have a role in the therapy of dyslipidemia, diabetes, and Parkinson disease; however, studies were limited and provided inconsistent dosing information, making it difficult to provide recommendations. Additionally, the 2-hour glucose pooled estimate from 7 trials was significant (P < 0.001). Studies in patients with type 2 diabetes and hypercholesterolemia have used from 1 g/day of a hydroalcoholic extract of fenugreek up to 100 g/day of germinated fenugreek seeds, whereas seed powder 1.8 to 2.7 g taken 3 times daily for the first 3 days of menstruation was used in primary dysmenorrhea (total daily dose, 5.4 to 8.1 g); 500 mg twice daily of a standardized extract was studied for management of postmenopausal symptoms. This is only a brief summary of general information about this product. Animal studies have demonstrated abortifacient effects in females and antifertility effects in males and females; whereas congenital malformations have been observed in humans as well as animals. Other names for the herbal spice include Greek hay, Greek hay seed, bird’s foot, Greek clover, foenugreek, sicklefruit fenugreek, hu lu ba, alholva, … Bleeding may occur. Fenugreek seeds have been used as an oral insulin substitute, and seed extracts have been reported to lower blood glucose levels. It should also be manufactured by a reliable company that uses GMP certified facilities and have few additional ingredients. Additionally, effects of fenugreek on lipid parameters were assessed and the pooled data revealed a significant decrease with fenugreek on triglycerides (â0.27 mmol/L; P=0.01) and total cholesterol (â0.30 mmol/L; P=0.03). Fenugreek Seeds are indicated in most of the diseases, but the Fenugreek leaves are commonly used as food additive. Cross-reactivity to legumes is possible; consider allergy potential with chickpea, peanuts, soybeans, lentils, lupin, green peas, or coriander. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. On the other hand, foenum graecum means "Greek hay" and it is thought to be assigned by the Romans who got the plant from Greece , where the fenugreek plant has been a common crop since ancient times. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Studies have included T lymphoma cells, squamous cell, breast, pancreatic, and prostate cancer, among others.24, 25, 26, 27, 28, 29, 75. Consider therapy modification.56, 57, 58, 59, Thrombolytic agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of thrombolytic agents. Fenugreek actually prevents the aggregation of platelets together, which is the mechanism by which one of the most common blood thinners, aspirin, works as well.
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